meiotic recombination

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You are studying meiotic recombination in mice and have isolated various mutations in the Spo11 gene. One mutation is a nonsense mutation in the first exon of Spo11. Another mutation is a missense mutation that results in temperature-sensitive allele of Spo11. A mouse that is heterozygous for the nonsense mutation (other allele is wildtype) is crossed with a mouse that is homozygous for the missense mutation, which has been kept at the permissive temperature from an early embryonic stage. Which of the following is a correct prediction of what phenotypes would be observed in the progeny from this cross? Assume Spo11 is haplosuffcient. 10. (2pts) If you perform the same cross as described in the question above, but the parent that is homozygous for the missense mutation was kept at the restrictive temperature from an early embryonic stage, which of the following is a correct prediction of what phenotypes would be observed in the progeny from this cross

 

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