. Everyone gets Ca2+!: Calcium is required for both long term potentiation (LTP) and long term depression (LTD). How is it possible that an influx of calcium ions into a post synaptic cell does not activate both LTP and LTD pathways? Describe the differences between the LTP and LTD mechanisms in Schaffer collateral-CA1 synapses and how calcium plays a key role in different ways. Be specific as to the different key molecules involved. 2. Synaptic Input: Neuron A receives excitatory inputs from neurons B and C. The excitation from neuron B arrives at the same time as that of neuron C. Do these excitatory components sum linearly? Why or why not? Sketch what the summed inputs would look like, and sketch what the actual synaptic input looks like. How do active conductances affect this summation? (NMDA or gated channels).

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Everyone gets Ca2+!: Calcium is required for both long-term potentiation (LTP) and long-term depression (LTD). How is it possible that an influx of calcium ions into a postsynaptic cell does not activate both LTP and LTD pathways? Describe the differences between the LTP and LTD mechanisms in Schaffer collateral-CA1 synapses and how calcium plays a key role in different ways. Be specific as to the different key molecules involved.2. Synaptic Input: Neuron A receives excitatory inputs from neurons B and C. The excitation from neuron B arrives at the same time as that of neuron C. Do these excitatory components sum linearly? Why or why not? Sketch what the summed inputs would look like, and sketch what the actual synaptic input looks like. How do active conductances affect this summation? (NMDA or gated channels).

 

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