a natural protein toxin that kills cells by inhibiting the synthesis of membrane proteins

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You discovered a natural protein toxin that kills cells by inhibiting the synthesis of membrane proteins. The toxin contains a stretch of 25 non-polar amino acids and a domain that enables penetration through the plasma membrane. You observed that the great decrease in rough ER but not smooth ER in treated cells. Which of the followings is likely the action mechanism of the toxin?

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