a. Gluconeogenesis occurs in cells in response to low glucose levels. You want to know if your particular cell line undergoes gluconeogenesis and therefore, compare cells grown in normal medium to those grown in very low glucose levels (starvation). What metabolites and enzyme activity do you look for to confirm gluconeogenesis is occurring? How would you effectively inhibit gluconeogenesis? b. Gluconeogenesis and glycolysis are both overall thermodynamically favorable in the cell. Given one is basically the reverse of the other, with many common enzymes and reversible reactions, how can this be?

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Gluconeogenesis occurs in cells in response to low glucose levels. You want to know if your particular cell line undergoes gluconeogenesis and therefore, compare cells grown in normal medium to those grown in very low glucose levels (starvation). What metabolites and enzyme activity do you look for to confirm gluconeogenesis is occurring? How would you effectively inhibit gluconeogenesis? b. Gluconeogenesis and glycolysis are both overall thermodynamically favorable in the cell. Given one is basically the reverse of the other, with many common enzymes and reversible reactions, how can this be?

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